Portfolio

Our current portfolio of projects

The ALBORADA Drug Discovery Institute is collaborating with academic researchers globally on a range of proteostasis focused projects. For a number of these projects we are collaborating with industry in order to access additional resources.

We are taking a broad approach to target identification, seeking novel targets and ideas from across the UK and globally. If you have molecular targets or hypotheses that could lead to new therapeutic approaches for neurodegenerative diseases, you can learn more about collaborating with the ALBORADA DDI here.

Publications

Computational Chemistry on a Budget: Supporting Drug Discovery with Limited Resources. J. Med. Chem. 2020. DOI: 10.1021/acs.jmedchem.9b02126

A Ferroptosis-Based Panel of Prognostic Biomarkers for Amyotrophic Lateral Sclerosis. Sci. Rep. 2019. DOI: 10.1038/s41598-019-39739-5

Recapitulating Parkinson’s Disease Pathology in a Three-Dimensional Human Neural Cell Culture Model. Dis. Model. Mech. 2019. DOI: 10.1242/dmm.038042

Therapeutics for Dementia and Alzheimer’s Disease: New Directions for Precision Medicine. Br. J. Pharmacol. 2019. DOI: 10.1111/bph.14767

The Proteostasis Network Provides Targets for Neurodegeneration. Br. J. Pharmacol. 2019. DOI: 10.1111/bph.14643

Chapter 11 – Neurodegenerative Diseases and Autophagy. The Molecular and Cellular Basis of Neurodegenerative Diseases. 2018. DOI: 10.1016/B978-0-12-811304-2.00011-0

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. Neuron. 2017. DOI: 10.1016/j.neuron.2017.01.022